Abstract: CuO-ZnO-Al2O3-ZrO2/HZSM-5 hybrid catalysts were prepared by a coprecipitation sedimentation method for the direct synthesis of dimethyl ether (DME) from CO2 hydrogenation. The prepared catalysts were characterized by XRD, BET, H2-TPR and NH3-TPD techniques. The hydrogenation process was carried out in a continuous flow pressurized slurry reactor using medical paraffin as a liquid medium under different temperature, pressure, H2/CO2 molar ratio and space gas velocity. The increase in reaction temperature is beneficial to improve the conversion of CO2, while the selectivity for DME is decreased. The increase in pressure and H2/CO2 molar ratio can improve both the conversion of CO2 and the selectivity for DME. While, the increase in the space velocity would decrease both the conversion of CO2 and the selectivity for DME.