化工进展 ›› 2021, Vol. 40 ›› Issue (8): 4647-4655.DOI: 10.16085/j.issn.1000-6613.2020-1846

• 资源与环境化工 • 上一篇    下一篇

高铁酸盐对水中H2受体拮抗剂的降解特性

方智煌(), 刘祥, 余阳, 钱雅洁(), 薛罡   

  1. 东华大学环境科学与工程学院,上海 201620
  • 收稿日期:2020-09-14 出版日期:2021-08-05 发布日期:2021-08-12
  • 通讯作者: 钱雅洁
  • 作者简介:方智煌(1995—),男,硕士研究生,研究方向为水污染控制理论与技术。E-mail:15980235762@163.com
  • 基金资助:
    国家自然科学基金青年基金(51708097);国家重点研发计划(2019YFD1100502)

Performance and properties of H2-receptor antagonist degradation by ferrate

FANG Zhihuang(), LIU Xiang, YU Yang, QIAN Yajie(), XUE Gang   

  1. College of Environmental Science and Engineering, Donghua University, Shanghai 201620, China
  • Received:2020-09-14 Online:2021-08-05 Published:2021-08-12
  • Contact: QIAN Yajie

摘要:

高铁酸盐[Fe(Ⅵ)]兼具氧化、絮凝和消毒等功能,是备受关注的一类多功能水处理剂。本文针对在自然水域中H2受体拮抗剂类药品(HRAs)经常被检出并难以去除的问题,通过高铁酸钾(K2FeO4)对5种临床上常见HRAs[即法莫替丁(FMTD)、雷尼替丁(RNTD)、罗沙替丁(RXTD)、西咪替丁(CMTD)和尼扎替丁(NZTD)]进行氧化降解研究。结果表明,在pH=7条件下,K2FeO4更倾向与带有硫醚键结构和羧基结构的HRAs反应。HRAs(除RXTD外)对K2FeO4具有较高的反应活性,降解率高达98.4%,并且符合二级反应动力学特性。反应二级速率常数与pH有较高的相关性,其主要是由于K2FeO4质子化和HRAs形态受pH的影响。不同浓度的水体基质(Cl-、HCO3-和腐殖酸)对K2FeO4氧化降解HRAs有不同程度的抑制作用。实际水体中复杂的水质特征影响K2FeO4对HRAs的去除,但除医疗废水外,K2FeO4对RNTD的去除率高达80%,医疗废水中的去除率为65%。经K2FeO4处理后,HRAs的生态毒性可显著降低。

关键词: 高铁酸钾, H2受体拮抗剂, 降解动力学, 实际水体, 生态毒性

Abstract:

Due to the well performance in oxidation, flocculation and disinfection, ferrate has raised increasing attention as a functional water treatment agent. H2-receptor antagonists (HRAs) as recalcitrant pollutants have been widely detected in natural environment. In this study, the widely used HRAs in clinic, i.e., famotidine (FMTD), ranitidine (RNTD), roxatidine (RXTD), cimetidine (CMTD) and nizatidine (NZTD) were selected as the target compounds to investigate the degradation performance of HRAs. The experimental results indicated that K2FeO4 was prone to react with the HRAs with thioether and carboxyl in structure. Except for RXTD, HRAs showed high reactivity towards K2FeO4, which removal efficiency was up to 98.4% and followed second-order degradation kinetics. Due to the protonation of K2FeO4 and the variation of HRAs species, the second-order rate constants were highly dependent on pH. The water matrices, i.e., Cl-、HCO3- and humic acid (HA), would scavenge HRAs degradation and the scavenger effect was dependent on the concentration of water matrices. As the complexity of real water samples, the removal of HRAs by K2FeO4 was affected. However, the removal efficiency of RNTD in different water samples was up to 80% except for hospital wastewater, in which it was only 65%. After treated by K2FeO4, the toxicity of HRAs was reduced significantly.

Key words: potassium ferrate, H2-receptor antagonist, degradation kinetics, real water, toxicity

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