Box-Behnken法优化不同孔径MCM-41包载β-胡萝卜素的处方工艺

doi:10.16085/j.issn.1000-6613.2015.09.030

化工进展 ›› 2015, Vol. 34 ›› Issue (09): 3392-3398.DOI: 10.16085/j.issn.1000-6613.2015.09.030

Box-Behnken法优化不同孔径MCM-41包载β-胡萝卜素的处方工艺

刘静, 翟婷婷, 于晓倩, 王海媛, 任智慧, 晋兴华

天津大学药物科学与技术学院, 天津 300072

收稿日期:2015-01-09 修回日期:2015-02-06 出版日期:2015-09-05 发布日期:2015-09-05
通讯作者: 晋兴华,博士,讲师。E-mail:snail9006@163.com
作者简介:刘静(1990-),女,硕士研究生。

Optimization of β-carotene loaded MCM-41 mesoporous silica by Box-Behnken design

LIU Jing, ZHAI Tingting, YU Xiaoqian, WANG Haiyuan, REN Zhihui, JIN Xinghua

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China

Received:2015-01-09 Revised:2015-02-06 Online:2015-09-05 Published:2015-09-05

摘要/Abstract

摘要： 采用三水平三因素的Box-Behnken实验设计,利用响应曲面法对影响MCM-41包载β-胡萝卜素包封率的主要因素进行研究,主要考虑的影响因素有载药时间、扩孔剂含量、β-胡萝卜素/MCM-41投药比等,以MCM-41对β-胡萝卜素的包封率作为评价因素,建立相应的数学模型,优化处方。结果表明,最优的处方工艺是载药时间为20h、扩孔剂含量为0.6mL、β-胡萝卜素/MCM-41投药比为3。在此条件下,β-胡萝卜素的包封率可达理论预测值的95.83%,说明将Box-Behnken实验设计法用于MCM-41包载β-胡萝卜素处方的优化筛选是可行的,且得到的实验观察值与数学模型的预测值相符合。

关键词: MCM-41, &beta, -胡萝卜素, Box-Behnken实验设计

Abstract: To optimize the formulation parameters of beta-carotene loaded MCM-41 mesoporous silica for the maximum encapsulation efficiency,experiments were designed according to a three-level,three-variable Box-Behnken design (BBD). Independent variables were the amount of pore enlarging agent (A),the beta-carotene/MCM-41 mass ratio (B),and loading time (C),and the response variable was the encapsulated efficiency of beta-carotene (Y_EE). The optimal formulation parameters were as follows:A,B and C levels were 0.6mL,3 and 20h,respectively. The observed responses agree with the predicted values of the mathematic models,and the Box-Behnken design is suitable for optimizing the formulation of beta-carotene loaded MCM-41 mesoporous silica.

Key words: MCM-41, β-carotene, Box-Behnken design

中图分类号:

R914.2

刘静, 翟婷婷, 于晓倩, 王海媛, 任智慧, 晋兴华. Box-Behnken法优化不同孔径MCM-41包载β-胡萝卜素的处方工艺[J]. 化工进展, 2015, 34(09): 3392-3398.

LIU Jing, ZHAI Tingting, YU Xiaoqian, WANG Haiyuan, REN Zhihui, JIN Xinghua. Optimization of β-carotene loaded MCM-41 mesoporous silica by Box-Behnken design[J]. Chemical Industry and Engineering Progree, 2015, 34(09): 3392-3398.

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Box-Behnken法优化不同孔径MCM-41包载β-胡萝卜素的处方工艺

Optimization of β-carotene loaded MCM-41 mesoporous silica by Box-Behnken design

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