关键词: 3-缩水甘油基丙基硅胶, 键合相, 硅烷偶联剂KH-560

Abstract: The bonded phase, 3-glycidoxypropyl silica gel, was prepared by the method of toluene reflux. The reaction conditions, including material ratio, reaction temperature and reaction time on the formation of bonded phase, were investigated through orthogonal test and one-factor test. The results indicated that the proper increasing of the content of KH-560, the reaction temperature and reaction time could promote the formation of bonded phase. But the results also showed that the overhigh reaction temperature and the overlong reaction time will cause the dissociation of KH-560. The suitable reaction conditions for the formation of silica gel and KH-560 bonded was：silica gel:KH-560 = 1:2 （ mass ratio）; reaction temperature 65?—80 ℃; reaction time 48—72 h. The decomposition of KH-560 can be avoided under this condition. Finally，compared with the hydrogen content between elemental analysis and theoretical calculation, it could be identified that there was only one methoxy group of the KH-560 molecule involved in the bonded reaction.

Key words: 3-glycidoxypropyl silica gel, bonded phase, KH-560