(R)-邻氯扁桃酸的制备技术进展

化工进展

(R)-邻氯扁桃酸的制备技术进展

钱晶，徐赛珍，薛亚平，郑裕国，沈寅初

浙江工业大学生物工程研究所，浙江杭州 310014

出版日期:2011-02-05 发布日期:2011-02-05

Progress of synthesis of (R)-2-chloromandelic acid

QIAN Jing，XU Saizheng，XUE Yaping，ZHENG Yuguo，SHEN Yinchu

Institute of Bioengineering，Zhejiang University of Technology，Hangzhou 310014，Zhejiang，China

Online:2011-02-05 Published:2011-02-05

摘要/Abstract

摘要：

(R)-邻氯扁桃酸是一种具有广泛用途的药物中间体和精细化工产品，主要用于抗血小板聚集药物氯吡格雷的合成，其制备方法主要包括不对称合成法和光学异构体拆分法。本文主要对(R)-邻氯扁桃酸的各种制备方法进行了介绍，并比较了不同制备技术的优缺点，最后对手性邻氯扁桃酸的催化合成前景进行了展望。

Abstract:

(R)-2-chloromandelic acid is one of the most important intermediates and fine chemicals with broad use. It can be used for the synthesis of clopidogrel，an anti-platelet drug that inhibits the ability of platelets to clump together as part of a blood clot. Presently，(R)-2-chloromandelic acid can be prepared by asymmetric synthesis and resolution of racemate. This review introduces various preparation methods of (R)-2-chloromandelic acid，and compares the advantages and disadvantages of these methods. The prospect of (R)-2-chloromandelic acid synthesis methods is also discussed.

钱晶，徐赛珍，薛亚平，郑裕国，沈寅初. (R)-邻氯扁桃酸的制备技术进展 [J]. 化工进展.

QIAN Jing，XU Saizheng，XUE Yaping，ZHENG Yuguo，SHEN Yinchu. Progress of synthesis of (R)-2-chloromandelic acid[J]. Chemical Industry and Engineering Progree.