左旋甲状腺素钠合成工艺的改进

化工进展

左旋甲状腺素钠合成工艺的改进

张文雯1，罗放2，陈绘如1，王炳恒1，吉民2

1常州工程职业技术学院，江苏常州 213164；2东南大学化学化工学院，江苏南京 210096

出版日期:2011-12-05 发布日期:2011-12-05

Improved synthesis of levothyroxine sodium

ZHANG Wenwen1，LUO Fang2，CHEN Huiru1，WANG Bingheng1，JI Min2

1Changzhou Institute of Engineering Technology，Changzhou 213164，Jiangsu，China；2College of Chemistry and Chemical Engineering，Southeast University，Nanjing 210096，Jiangsu，China

Online:2011-12-05 Published:2011-12-05

摘要/Abstract

摘要：

以L-酪氨酸为原料，六步法合成左旋甲状腺素钠。对左旋甲状腺素钠合成的关键步骤——偶联反应的催化剂进行了改进，考察了偶联反应催化剂用量、溶剂用量、反应温度、反应时间等因素对反应的影响。工艺经改进后，偶联收率达60.5%，比文献报道提高了18.5%，6步反应总收率为22.5%，比文献值提高了11.1%。

Abstract:

Levothyroxine sodium was synthesized from L-tyrosine as raw material by six-step reactions. The catalyst in the key step of coupling reaction was improved. Some factors of coupling reaction were analyzed including the effect of amount catalyst，solvent amount，reaction temperature and reaction time. Under the optimal reaction conditions，the yield of coupling reaction could reached up to 60.5%，which was about 18.5% higher than before，the total yield of levothyroxine sodium could reached up to 22.5%，which was about 11.1% higher than before.

张文雯1，罗放2，陈绘如1，王炳恒1，吉民2. 左旋甲状腺素钠合成工艺的改进[J]. 化工进展.

ZHANG Wenwen1，LUO Fang2，CHEN Huiru1，WANG Bingheng1，JI Min2. Improved synthesis of levothyroxine sodium[J]. Chemical Industry and Engineering Progree.