Abstract: The treatment of biorefractory wastewater is regarded as the key field and major task in the environmental planning of China. The methods to treat biorefractory wastewater include extraction，adsorption，incineration，chemical oxidation and biological oxidation. But each of these methods has its limitation. Combining advanced oxidation process（as a pre-treatment）with biological method is attractive for the treatment of biorefractory wastewater. This coupled process is effective for the degradation of pollutants and also cost effective. This paper reviews the study of the coupled process of photo-Fenton system and biological method in recent 10 years. Attention is paid on the type of wastewater treated by this coupled process and the determination of the optimal coupled point. Various biological reactors and comparison of different pre-treatment methods are also introduced. Finally，some suggestions for future study of the coupled process of photo-Fenton system and biological method are proposed.