Abstract: Camostat mesilate，a drug for pancreatitis treatment was prepared from p-guanidinobenzoic acid hydrochloride and N,N-dimethylcarbamoylmethyl-p-hydroxyphenylacetate in the presence of DCC（N,N-dicyclohexylcarbodiimide）using DMAP（4-dimethylaminopyridine）as catalyst. p-Guanidinobenzoic acid hydrochloride was prepared from p-aminobenzoic acid and cyanamide by optimization of reaction conditions. This process is simple with easily available starting materials，which is suitable for industrial production.