D-A环合芳构化法合成4-氯代苯酐

化工进展

D-A环合芳构化法合成4-氯代苯酐

孙一飞，张华

大连理工大学精细化工国家重点实验室，辽宁大连 116012

出版日期:2010-10-05 发布日期:2010-10-05

Synthesis of 4-chlorophthalic anhydride with D-A cyclization and aromatization

SUN Yifei，ZHANG Hua

State Key Laboratory of Fine Chemicals，Dalian University of Technology，Dalian 116012，Liaoning，China

Online:2010-10-05 Published:2010-10-05

摘要/Abstract

摘要：

为了寻找一条高效率合成4-氯代苯酐的路线，基于D-A环合原理和芳构化方法，首先，优化并比较了两条合成4-氯代四氢苯酐（二酸）的路线，然后，优化并比较了两条将4-氯代四氢苯酐（二酸）芳构化合成4-氯代苯酐的路线。得到如下结果：4-氯代四氢苯酐收率提高到95%，纯度大于98%；用液溴作芳香化试剂4-氯代苯酐的单步收率达到89%、纯度99%，氧气活性炭作芳香化试剂，4-氯代苯酐收率达到70%、纯度100%。

Abstract:

Synthesis of 4-chlorophthalic anhydride（acid）was investigated based on D-A cyclization and aromatization. Two synthetic routes for 4-chlorotetrahydrophthalic anhydride，and its two aromatizing ways were optimizated and compared. The yield of 4-chlorotetrahydrophthalic anhydride was increased to 95% with purity higher than 98%. The aromatization yield using liquid bromine as the aromatizing reagent was increased to 89% with 99% purity；and the aromatization yield using oxygen and activated carbon as the aromatizing reagent was increased to 70% with 100% purity.

孙一飞，张华. D-A环合芳构化法合成4-氯代苯酐 [J]. 化工进展.

SUN Yifei，ZHANG Hua. Synthesis of 4-chlorophthalic anhydride with D-A cyclization and aromatization[J]. Chemical Industry and Engineering Progree.