Abstract: During the three-step preparation of Galaxolide with α-methyl styrene，tert-amyl alcohol，propylene oxide and polyformaldehyde as starting materials，some factors have been analyzed including the effect of catalyst on the formation of indene，the effect of solvent on the formation of indanol and the effect of catalyst on the formation of Galaxolide. Finally，a better synthetic process for Galaxolide was identified，which is more environmentally benign and more cost-effective.