Abstract: Titanosincalite TS-1 has attracted much attention due to its excellent catalytic properties in the partial oxidation of organic compounds. The fundamental research and the syntnetic studies on TS-1 have become a hotspot in catalytic field．Recent developments in the synthesis，modification and catalytic properties of titanium silicalite molecular sieve are reviewed，including the developments in the synthesis of TS-1 with hydrothermal and isomorphous replacement methods，the modification of TS-1，as well as applications in catalytic oxidation and acid catalysis systems.