Abstract: Impinging Stream - Rotating Packed Bed (IS-RPB) as a new study field for high gravity to intensify process of liquid-liquid contact and its process mechanism are presented. The mixing process and its principle as well as experimental effect are introduced in particular. The mixing effect is contrasted between IS-RPB and general mixing sets. Based on IS-RPB separation application and contrast to general ways，the basic research and application study for liquid–liquid extraction and liquid membrane separation are discussed. According to chemical reaction engineering，IS-RPB is a feasible reactor for liquid–liquid two phase reaction，and it，as a reactor，can be used to prepare ultra-fine powder. The development direction and progress of IS-RPB are prospected.