Abstract: In the process of hydrocracking，some process variables，such as temperature of catalyst，have critical influence on the quality of final products. In industrial production，the real-time data from DCS usually can not be integrated with the quality data from laboratory，which resulted in the waste of data and investment. A production guiding system is proposed in this paper. Through collecting the real-time data from DCS and the quality data from laboratory，mathematical relations between some process variables and production quality indexes would be obtained as to guide users to adjust process variables and improve the quality of final products. Such system has been proved to be effective in practice.