Abstract: V2O5-MoO3-P2O5/γ-Al2O3 loaded catalysts were prepared by impregnation for the oxidation of furfural to maleic anhydride. The physicochemical properties and textural character of the catalysts were studied by using ICP，N2 adsorption and XRD. The crystal lattice oxygen in the catalysts was investigated through a method of temperature-programmed reduction (TPR). The catalytic behavior of the catalysts for the oxidation of furfural was evaluated in a continuous fixed bed reactor，in which a reacting gas stream of 2% furfural in air was passed through the catalyst at 305 ℃ with 3000 h-1 of gas velocity. When the quality ratio of MoO3/V2O5 was 0.4，the conversion of furfural was 82% and the yield of maleic anhydride reached to 50%，indicating that the introduction of MoO3 could adjust the interaction between the supporter and the active center. Hence，the rapid exchange of crystal lattice oxygen in the catalysts could be accelerated，and the activity and selectivity of catalysts were remarkably improved.