Abstract: The poly-L-lactic acid (PLLA) scaffold reinforced by nano-hydoxyapatite (HAP) was prepared by the thermal induced phase separation method，and the morphology，porosity，mechanical property and in vitro degradation were investigated. The scaffold had three dimensional porous structure with nano-fibrous matrices. The compressive modulus of the composite scaffold reached a maximum when the mass ratio of PLLA and HAP was 80∶20，2.15 folds as compared with that of the pure nano-PLLA scaffold. The porosity of the scaffolds was higher than 88%. The results of the in vitro degradation suggested that adding nano-HAP into the PLLA scaffold depressed the degradation effectively.