Abstract: Differential evolution (DE) algorithm has many advantages，such as global optimum and high efficiency. A new predictive control algorithm based on DE was proposed，using DE to get the optimal control value. The algorithm had nothing to do with the type of the model，and it could be used in both linear and non-linear objects. The algorithm combined dynamic control and optimization in an index function，and used single-value predictive control. Application of the algorithm in CDU obtained good results，showing the feasibility and efficiency of the algorithm.