Abstract: The temperature of feed air and desorption parameters，such as the inner diameter and length of the pipe for desorption were measured in oxygen generation by pressure swing adsorption. The result showed that thinner and longer pipe could lead to more easy penetration of oxygen in adsorption bed during the adsorption step. Oxygen with a lower concentration would reach the top of the adsorption bed during adsorption and desorption，resulting in lower oxygen concentration and decreased flow rate. The feed air with a higher temperature would enhance the regeneration of molecular sieve，and the oxygen concentration increased by 1.2% per 10 ℃ between 15 ℃ and 65 ℃.