Abstract: The effect of different additives and their contents on the catalyst of hydrorefining for VGO was investigated. The results indicated that the additive added by use of a unique method could change the nature of support surface，especially the function of acidity，which resulted in high activity，large surface area，concentrated pore distribution and favorable acidity of the catalyst. When the content of the additive was 3%，the catalyst had the highest activity. From the test results，the reaction temperature of the developed catalyst was 4℃ lower than the reference catalyst on the condition that the same quality products were obtained. The result of 1500 h run time experiment indicated good stability of the catalyst.