Abstract: The hydrogen bonds in polymer blends is an interesting and important subject of research as its presence usually enhances the miscibility of the blends. Here, the factors affecting the formation and stability of hydrogen bonds, the effects of hydrogen bonds on the miscibility and properties of blends, and methods to incorporate inter-molecular hydrogen bonds into immiscible blends are reviewed, some typical inter-molecular hydrogen bonding complexes’s applications are also introduced, based on the work worldwide in the recent decade.