Abstract: Cyclodextrin immobilized chitosan is a kind of novel functional macromolecule that possesses the cumulative effects of inclusion，size specificity，controlled release ability and transport properties of cyclodextrin as well as the biocompatibility，non-toxicity，and biodegradatibility of chitosan. It can be used in many types of applications，such as delivering drugs，treatment of waste water and chromatographic support. This paper reviewes the recent study on different methods of cyclodextrin grafting onto chitosan or its derivatives and discusses its applications.