Abstract: (E)-1-phenylsulfonyl-2-methyl-4-hydroxy-2-butene（product A）was synthesized through the three-step process（addition，acetolysis and saponification）by using isoprene as the starting material and purified by crystallization from ether-ethyl acetate mixtures. 6-(4-phenylsulfonyl-3-methyl-2- butenyl)-2,3-dimethoxy-5-methylhydroquinone-O,O′-dibenzyl ether（product B）was synthesized by coupling reaction between hydroquinone and product A by using heteropoly acid as catalyst and with the hydroxyl group on hydroquinone protected by bromobenzyl. The end product B was purified by crystallization from ether-diisopropyl ether mixtures. The influence factors of the synthesis process were also studied. The yield of end product B was 75%（based on product A）. This process has distinct advantages，such as simple process，much milder reaction conditions，green chemical catalytic technology and so on. The structures of product A and end product B were identified by FTIR and 1H NMR.