Abstract: The method of butyramide synthesis through hydration reaction of butyronitrile with water was studied. It was found that the highest activity of that Cr/Cu catalyst was obtained when the molar ratio of NaH2PO2/CuSO4 was 1.50—1.60 and that of Cr/Cu was 0.004—0.006 at the highest reaction temperature range of 55—57 ℃. The experimental results showed that the conversion rate of butyronitrile was up to 100% under the optimal reaction condition of the feed molar ratio of butyronitrile and water 1∶4.8，Cr/Cu catalyst concentration 22%—25%, reaction temperature 95—100 ℃ and residence time 5—6 h. In the experimental production conducted by the new process flow，the conversion rate of butyronitrile was 99% and the purity and yield of butyramide reached above 90 g·h－1 and 99.9% respectively.