Abstract: Mesoporous，organic-inorganic hybrid SBA-15-SO3H containing alkyl(methyl) and sulfonic acid groups was directly synthesized. The catalyst was effective in the synthesis of 2-t-butyl-p-cresol by the alkylation of MTBE with p-creso. Moreover，the influence of alkylation reaction condition on the conversion and selectivity of alkylation and the stability of catalyst was investigated. The experimental result showed that the conversion rate of p-cresol was 87.4%，the selectivity rate was 97.86%，SBA-15-SO3H molecular sieve was an ideal catalyst for the synthesis of 2-t-butyl-p-cresol.