Abstract: SnO2 nanoparticles with rutile structure were prepared by the homogeneous precipitation method in the submerged circulating impinging stream reactor，using SnCl4·5H2O and urea as the raw materials，and the SnO2 powder was characterized by means of XRD and TEM. The effects of reaction temperature，ratio of reactants，reaction time，calcination time and rotating speed of propellers on the yield of the product were investigated. The results showed that reaction time was the main factor that affected the yield of SnO2，while the reaction temperature and the rotatng speed of propellers were the minor factors. The particles with average size of 20 nm，fine dispersion and narrow size distribution were obtained under optimal conditions.