Abstract: The structure，performance，synthesis methods and development trends of neotame are introduced in this paper. Especially，the methods to synthesize neotame are described in detail and compared with each other. The process of chemical synthesis is simple，whereas this method gives a lower yield of product. The advantage of chemical-enzyme synthesis is high enzyme specificity but the disadvantage is higher cost of zymolysis. It is found that using aspartame as raw material to synthesize neotame is the most promising process because aspartame is cheap and readily available.