Abstract: The present status of deactivation and regeneration of titanium silicalite in main catalytic oxidation reactions，such as alkene epoxidation，cyclohexanone ammoxidation，phenol hydroxylation，etc. is reviewed. Pore blocking by reaction byproducts is the main reason for catalyst deactivation，and titanium leaching or silica dissolution is another reason.The present regeneration methods are summarized，and their effects on zeolite structure and catalytic performance are also presented.The research prospect of regeneration of titanium silicalite is discussed.