Abstract: Supercritical fluid (SCF) technology is an important field of green chemistry. Due to the restriction of high pressure，most traditional detection methods are not applicable to obtaining the data of physical and chemical properties，which greatly affects the research and applications of SCF. Quartz crystal microbalance (QCM) is a new sub-micro weighing technique that can work under extreme conditions，such as high temperature，high pressure with good precision. Therefore it can be conveniently used for the detection of SCF processes. Combining with the research work in our laboratory，the paper introduces the fundamental theory and characteristics of QCM，and especially reviews and predicts the applications of QCM in supercritical carbon dioxide (ScCO2) .