化工进展

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应用超临界流体重结晶技术制备药物微粒

刘 燕;王威强;邢晓伟   

  1. 山东大学机械工程学院
  • 出版日期:2007-03-25 发布日期:2007-03-25

Preparation of superfine medicament particles by supercritical fluids recrystallization technology

LIU Yan;WANG Weiqiang;XING Xiaowei   

  1. School of Mechanical Engineering,Shandong University
  • Online:2007-03-25 Published:2007-03-25

摘要: 总结了超细药物微粒的常规制备方法,对超临界重结晶技术的两种常用方法,即超临界流体快速膨胀法和抗溶剂法进行了介绍,阐述了它们的应用进展情况,回顾了两种方法在国内中药药材领域的研究情况。并对超临界重结晶技术进行了展望,指出该技术为我国中药材有效成分的精细制备提供了一条富有前景的道路,但需要解决制备产量低、成本高、工艺和设备尚不完善等问题。

Abstract: The conventional methods of preparing superfine medicament particles are presented. Two common methods of supercritical fluids recrystallization,rapid expansion of supercritical solution and supercritical anti-solvent crystallization are introduced. Their applications are presented,and the research work in the field of Chinese traditional medicine is reviewed. The prospect of supercritical fluids recrystallization technology as a new way to prepare fine particles of Chinese traditional medicine is also presented. Some problems still exist,such as low yield,high cost,and the technique and equipment are to be improved.

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