Abstract: Transition metal modified nano-titanium dioxide was prepared by the sol-gel method and characterized. Desulfurization of sulfur compounds in FCC naphtha with the prepared catalyst was investigated. The effects of TiO₂ dosage，addition of tetrabutyl ammonium bromide, doping by Fe, Ni, Cu, Zn and reaction time on desulfurization performance were studied. Test results showed that under the conditions of using FCC naphtha，a volume ratio of naphtha to formic acid of 1∶1，7.5％（mol）Ni-TiO₂ 20mg，adding 5mg tetrabutyl ammonium bromide，illumination 3h，desulfurization rate was up to 98.4%.