Abstract: Dispersion of nano-particles in paint was studied. In order to enhance the dispersion of nano-particles in the fluorocarbon paint，the influence factors of dispersion stability of nano-TiO2 in the fluorocarbon paint were discussed in terms of the physical，mechanical and surface modification principles. The experiment results indicated that the dispersion of nano-TiO2 in the fluorocarbon paint could be improved by adding 731A，Tween80 and Tritonx100 etc and by mechanical dispersing at 6 000 r/min and 60 min，ultrasonic dispersing 30 min etc. At the same time，the anti-contamination and anti-washing performance of the nano-TiO2 fluorocarbon paint were improved.