Abstract: Based on process mechanism analysis, this paper presents an application of advanced process control strategy to resolve the practical issues of ethylene glycol distillation system. The inferential control, decouple control, and expert control technologies are applied and integrated with distributed control system seamlessly. And operation conditions are optimized based on exact industrial process models for ethylene glycol distillation system. As a result of these work, control stability is improved obviously, energy consumption decreases effectively, and operation period is prolonged.