白果的特异生物活性和药理作用研究进展

doi:10.16085/j.issn.1000-6613.2017-1256

化工进展 ›› 2017, Vol. 36 ›› Issue (S1): 366-371.DOI: 10.16085/j.issn.1000-6613.2017-1256

白果的特异生物活性和药理作用研究进展

赵珮妮, 和法涛, 宋烨, 吴茂玉, 葛邦国, 刘光鹏

中华全国供销合作总社济南果品研究院, 山东济南 250014

收稿日期:2017-06-21 修回日期:2017-07-11 出版日期:2017-12-31 发布日期:2017-12-13
通讯作者: 吴茂玉,博士,研究员。
作者简介:赵珮妮(1985-),女,博士研究生,助理研究员,研究方向为果蔬资源化学与应用。
基金资助:
山东省泰山产业领军人才工程高效生态农业创新类项目（LJNY2015004）及十三五国家重点研究开发计划项目（2016YFD0400700，2016YFD0400704-3）。

Research progress of specific bioactivity and pharmacological action of Ginkgo seeds

ZHAO Peini, HE Fatao, SONG Ye, WU Maoyu, GE Bangguo, LIU Guangpeng

Jinan Fruit Research Institute, All China Federation of Supply & Marketing Co-operatives, Jinan 250014, Shandong, China

Received:2017-06-21 Revised:2017-07-11 Online:2017-12-31 Published:2017-12-13

摘要/Abstract

摘要： 白果（银杏果）是一种含有丰富营养成分和特异生物活性物质的药食同源性植物资源。目前已发现其具有多种药理功能。白果中的多糖、内酯及蛋白等有效成分受到国内外研究者的关注，并在其提取纯化技术及功效评价方面进行了深入研究。我国是白果产量大国，具有丰富的白果种质资源，但是我国白果的深加工产业水平较低，白果资源没有得到有效利用，白果价值没有充分实现。针对上述问题，本文对白果活性成分的提取分离技术和生物活性等研究进展进行综述，并就国内外关于白果活性成分的药理作用方面的研究进行分析，对白果功能产品进行展望，旨在对我国白果产业进行一定引导及激励，引发对白果这一优质资源的更多关注和开发，促进国内白果产业的快速发展。

关键词: 白果, 提取分离, 生物活性, 药理作用, 功能产品

Abstract: Ginkgo biloba seed is one of the medicinal and edible plant resources enriched in nutrients and specific biological activity substances. It has been found that Ginkgo seed has a variety of pharmacological function. The effective components such as polysaccharide, lactone and protein in Ginkgo biloba have been concerned by researchers at home and abroad, and studied in the field of extraction, purification and efficacy evaluation. China is a country with large Ginkgo production, where Ginkgo germplasm resources are rich. However, the Ginkgo deep processing industry level in China is relatively low, which results that the Ginkgo resources have not been effectively utilized and the value of Ginkgo has not been fully realized. In response to these problems, the methods of extraction, isolation and biological activity of Ginkgo seed, as well as its pharmacological action in domestic and foreign studies have been reviewed. The future of Ginkgo seed functional products has been prospected. The aim is to guide and stimulate the Ginkgo seed industry in China, to raise the attention and development of Ginkgo seeds, and to promote the rapid development of the domestic Ginkgo industry.

Key words: Ginkgo seed, extraction and isolation, bioactivity, pharmacological action, functional products

中图分类号:

TS255

赵珮妮, 和法涛, 宋烨, 吴茂玉, 葛邦国, 刘光鹏. 白果的特异生物活性和药理作用研究进展[J]. 化工进展, 2017, 36(S1): 366-371.

ZHAO Peini, HE Fatao, SONG Ye, WU Maoyu, GE Bangguo, LIU Guangpeng. Research progress of specific bioactivity and pharmacological action of Ginkgo seeds[J]. Chemical Industry and Engineering Progress, 2017, 36(S1): 366-371.

参考文献

[1] BEEK T A V, MONTORO P. Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals[J]. Journal of Chromatography A, 2009, 1216:2002-2032.
[2] DEGUCHI J, HASEGAWA Y, TAKAGI A, et al. Four new Ginkgolic acids from Ginkgo biloba[J]. Tetrahedron Letters, 2014, 55:3788-3791.
[3] PINTO M D S, KWON Y I, APOSTOLIDIS E, et al. Potential of Ginkgo biloba L. leaves in the management of hyperglycemia and hypertension using in vitro models[J]. Bioresource Technology, 2009, 100:6599-6609.
[4] YAMAMOTO S, NAKANO K, ISHIKAWA C, et al. Enhanced inhibitory effects of extracts from Ginkgo bilobal. leaves encapsulated in hybrid liposomes on the growth of tumor cells in vitro[J]. Biochemical Engineering Journal, 2002, 12:125-130.
[5] 中国科学院植物研究所主编. 中国高等植物图鉴第一册[M]. 北京:科学出版社, 1985:286.
[6] 中华人民共和国国家质量监督检验总局. GB19336-2003阿维菌素原药[S]. 北京:中国标准出版社, 2004.
[7] WU X Y, MAO G H, ZHAO T, et al. Isolation, purification and in vitro anti-tumor activity of polysaccharide from Ginkgo biloba sarcotesta[J]. Carbohydrate Polymers, 2011, 86:1073-1076.
[8] CHEN J J, ZHANG T, JIANG B, et al. Characterization and antioxidant activity of Ginkgo biloba exocarp polysaccharides[J]. Carbohydrate Polymers, 2012, 87:40-45.
[9] 王琴, 邹杰, 温其标. 超声强化提取银杏多糖[J]. 食品与发酵工业, 2006, 32(1):126-128.
[10] 李新华, 杨强, 王琳. 微波辅助提取银杏白果多糖的工艺研究[J]. 食品科技, 2012, 37(4):160-163.
[11] LEE J H, PARK J S, LEE S W, et al. Porcine epidemic diarrhea virus infection:inhibition by polysaccharide from Ginkgo biloba exocarp and mode of its action[J].Virus Research, 2015, 195:148-152.
[12] XU A H, CHEN H S, WANG L, et al. Influence of Ginkgo biloba L. exocarp polysaccharides on serum superoxide dismutase activity and malondialdehyde level in mice under different states[J]. Journal of Chinese Medicinal Materials, 1998, 23:746-747.
[13] XU A H, CHEN H S, SUN B C, et al. Therapeutic mechanism of Ginkgo biloba exocarp polysaccharides on gastric cancer[J]. World Journal of Gastroenterology, 2003, 9, 2424-2427.
[14] 许爱华, 陈华圣, 孙步蟾. 银杏外种皮多糖对HL-60细胞的体外实验研究[J]. 中药材, 2004, 27(5):361-363.
[15] 陈群, 杨桂文, 安利国. 银杏白果多糖的提取、纯化和分析[J]. 中国药学杂志, 2002, 37(5):331-333.
[16] ZHANG X T, LI Y, ZHANG L H, et al. A new ginkgolide from Ginkgo biloba[J]. Journal of China Pharmaceutical University, 2009, 40(4):306-309.
[17] 郭瑞霞, 李骘, 李力更, 等. 天然药物化学史话:银杏内酯[J]. 中草药, 2013, 44(6):641-645.
[18] 唐世蓉,周爱玲,赵友谊,等. 银杏叶中银杏内酯B及白果内酯的分离鉴定[J]. 植物资源与环境, 1992, 1(l):58-59.
[19] 潘见, 张文成, 谢慧明. 超临界CO₂萃取结晶银杏内酯关键工艺参数研究[J]. 食品科学, 2004, 25(3):132-134.
[20] 陈啸天, 何珺, 谢倩红, 等. 大孔树脂对银杏根皮中银杏内酯C富集工艺研究[J]. 广东化工, 2015, 42(17):55-56.
[21] 钦富华, 黄孝闻, 夏晓静, 等. 大孔吸附树脂法同时纯化银杏叶中黄酮苷和萜类内酯[J]. 广东药学院学报, 2013, 29(2):142-146.
[22] SMITH P F, MACLENNAN K, DARLINGTON C L. The neuroprotective properties of the Ginkgo biloba leaf:a review of the possible relationship to platelet-activating factor (PAF)[J]. Journal of Ethnopharmacology, 1996, 50:131-139.
[23] OYAMA Y, CHIKAHISA L, UEHA T, et al. Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide[J]. Brain Research, 1996, 712:349-352.
[24] BRAQUET P. The ginkgolides:potent platelet activating factor antagonists isolated from Ginkgo biloba l:chemistry, pharmacology and clinical applications[J]. Drug of the Future, 1987, 12:643-699.
[25] HOSFORD D, BRAQUET, P. Antagonists of platelet-activating factor:chemistry, pharmacology and clinical applications[J]. Progress in Medicinal Chemistry, 1992, 27:325-380.
[26] RODRÍGUEZ M, RINGSTAD L, SCHÄFER P, et al. Reduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb761) in cardiovascular high-risk patients[J]. Atherosclerosis, 2007, 192:438-444.
[27] 邓虹珠, 易延逵. 银杏内酯的研究进展[J]. 南方医科大学学报, 2001, 21(s1):91-93.
[28] 唐远鹏, 曾靖, 黄起壬. 白果内酯药理作用的研究[J]. 赣南医学院学报, 2015, 35(1):153-155.
[29] FAN L P, DING S D, LIU Y F, et al. Dehydration of crude protein from Ginkgo biloba L. by microwave freeze drying[J]. International journal of biological macromolecules, 2012, 50(4):1008-1010.
[30] DENG Q C, WANG L, WEI F, et al. Functional properties of protein isolates, globulin and albumin extracted from Ginkgo biloba seeds[J]. Food Chemistry, 2011, 124:1458-1465.
[31] HUANG W, XIE B J, WANG Y, et al. Study on separation and purification of protein from Ginkgo seed and its antioxidant activity[J]. Scientia Agricultura Sinica, 2004, 37(10):1537-1543.
[32] 黄文, 谢笔钧, 王益, 等. 白果蛋白质的分离、纯化、理化特性及其抗氧化活性研究[J]. 中国农业科学, 2004,37(10):1537-1543.
[33] HALLIWELL B, GUTTERIDGE J M C, ARUOMA O I. The deoxyribose method:a simple "test-tube" assay for determination of rate contents for reactions of hydroxyl radicals[J]. Analytical Biochemistry, 1987, 165:215-219.
[34] SAWANO Y, MIYAKAWA T, YAMAZAKI H, et al. Purification, characterization, and molecular gene cloning of an antifungal protein from Ginkgo biloba seeds[J]. Biological Chemistry, 2007, 38:273-280.
[35] WANG H X, NG T B. Ginkbilobin, a novel antifungal protein from Ginkgo biloba seeds with sequence similarity to embryoabundant protein[J]. Biochemical and Biophysical Research Communications, 2000, 279:407-411.

白果的特异生物活性和药理作用研究进展

Research progress of specific bioactivity and pharmacological action of Ginkgo seeds

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