关键词: β-酮酸酯, 不对称α-羟基化, 有机催化, 不对称催化

Abstract: The chiral α-hydroxy-β-dicarbonyl is a common structural motif in a variety of natural products and pharmaceuticals and the most convenient way to obtain chiral α-hydroxylation compounds is the direct asymmetric oxidation of 1,3-dicarbonyl compounds.Thus,research on enantioselective α-hydroxylation of β-keto esters possess great value.This paper makes a brief summary of cinchona alkaloid derivatives,diterpenoid alkaloid derivatives,S-timolol analogues and phase-transfer catalysts applied to direct enantioselective hydroxylation of β-keto ester compounds.The possible mechanism of these catalysts is believed to be the outcome of combined action of various intermolecular forces,namely hydrogen bonding,π-π stacking and electrovalent bonding.

Key words: β-keto esters, enantioselective α-hydroxylation, organocatalysts, asymmetric catalysis