关键词: 中空介孔二氧化硅球, 吲哚美辛, Box-Behnken实验, 包封率

Abstract: The hollow mesoporous silica nanoparticles (HMSN) were synthesized in neutral aqueous solution at room temperature. Following this method, well-defined HMSN was prepared with a 25nm shell and a 250nm hollow diameter. Nitrogen adsorption-desorption analysis, Trans-mission electron microscopy, Fourier Transform Infrared Spectrometer were applied to characterize the synthesized HMSNs. The morphology of the HMSN was spherical. The BET result shows that the specific surface area of HMSN was 730.0m²/g, the average pore size was 1.084cm³/g, and the pore diameter was 6.58 nm. Experiments were designed according to a three-level Box-Behnken design to optimize the Indomethacin loaded HMSNs. The result indicated that HMSNs exhibited an excellent drug loading capacity. The optimal formulation parameters were as follows:IMC/HMSNs mass ratios (A), loading time (B) and ultrasonic time (C) levels were 22:1, 1.4h and 23h, respectively and the best encapsulation efficiency could be 85.2%. The observed responses were in good agreement with the predicted values of the mathematic models, so the Box-Behnken design is suitable for optimizing the formulation of indomethacin loaded hollow mesoporous silica nanoparticles.

Key words: HMSNs, indomethacin, Box-Behnken design, encapsulation efficiency