基于静电纺丝技术的PLGA载药纳米纤维膜的制备工艺

doi:10.16085/j.issn.1000-6613.2015.03.031

化工进展 ›› 2015, Vol. 34 ›› Issue (3): 790-796.DOI: 10.16085/j.issn.1000-6613.2015.03.031

基于静电纺丝技术的PLGA载药纳米纤维膜的制备工艺

朱同贺¹, 陈思浩², 楼建中^3,4,5, 王继虎³, 李洋³, 廖健俊³

1. 上海工程技术大学服装学院, 上海 201620;
2. 上海工程技术大学科研处, 上海 201620;
3. 上海工程技术大学化学化工学院, 上海 201620;
4. 北卡罗莱纳农工州立大学化工与生物医学工程系, 格林波诺 NC 27411, USA;
5. 上海工程技术大学先进材料跨学科中心, 上海 201620

收稿日期:2014-08-18 修回日期:2014-09-14 出版日期:2015-03-05 发布日期:2015-03-05
通讯作者: 陈思浩,教授,硕士生导师,主要从事生物医药领域新制剂及其新材料的研究开发。E-mail:haosihaosi@163.com。
作者简介:朱同贺(1988-),男,硕士研究生。E-mail:zhutonghe@gmail.com。
基金资助:
上海市科委地方高校能力建设项目(11490501500)及上海高校学科专业建设项目(11XK18B,XKCZ1205)

Preparation of drug-loaded polylactic acid-based fibers membranes based on electrospinning technology

ZHU Tonghe¹, CHEN Sihao², LOU Jianzhong^3,4,5, WANG Jihu³, LI Yang³, LIAO Jianjun³

1. School of Fashion Design, Shanghai University of Engineering Science, Shanghai 201620, China;
2. Scientific Research Department, Shanghai University of Engineering Science, Shanghai 201620, China;
3. School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China;
4. Department of Chemical Engineering and Biomedical Engineering, North Carolina A&T State University, 1601 E.Market St, Greensboro, NC 27411, USA;
5. Multidisciplinary Center for Advanced Materials of Shanghai University of Engineering Science, Shanghai University of Engineering Science, Shanghai 201620, China

Received:2014-08-18 Revised:2014-09-14 Online:2015-03-05 Published:2015-03-05

摘要/Abstract

摘要： 同轴静电纺丝法制备的聚乳酸-乙醇酸(PLGA)纳米纤维具有良好的生物相容性和生物可降解性, 加之其高孔隙率和高透氧率, 使其能成为优良的药物载体。本文初步摸索了PLGA的同轴静电纺丝的工艺条件, 并通过同轴静电纺丝法制备了PLGA载氟比洛芬酯(FA)的纳米纤维膜, 应用扫描电子显微镜、红外光谱分析观察纤维的表观形貌并确定其微观结构。重点探究了不同溶剂配比的混合溶剂对载药纤维膜药物释放性能影响。研究结果表明在U⁺为+15.00kV, U^-为-2.50kV, 接受距离为15cm, 壳层推进速度为0.4mm/min, 芯层推进速度为0.1mm/min进行静电纺丝时, 所制备的PLGA(壳)/PVP+FA(核)复合载药纤维膜壳核结构良好, 且成功载了约0.5%的FA。当改变壳层混合溶剂(DCM和DMF)和芯层混合溶剂(无水乙醇和DMF)体积比时, 纤维直径会随着DMF的减少而增大。

关键词: 聚乳酸-羟基乙酸, 同轴静电纺丝, 氟比洛芬酯, 控释制剂

Abstract: PLGA [poly(1actic-co-glycolic acid)] coaxial electrospinning nanofiber is a biodegradable material with good biocompatibility. In addition, its high porosity and high oxygen permeability would also favor PLGA to become a good pharmaceutical carrier. The technological conditions of electrospinning were studied and flurbiprofen axetil (FA)-loaded PLGA nanofibers were prepared by coaxial electrospinning. The structure and morphology of the nanofiber were characterized by infrared spectrometer (IR) and scanning electron microscope (SEM), respectively. The influence of solvent's proportion on nanofibers'drug release properties was investigated. When positive voltage, negative voltage, receive distance, advancing speed of the shell as well as the core is+15.00kV, -2.50kV, 15cm, 0.4mm/min, 0.1mm/min, respectively. The prepared PLGA/PVP FA-loaded electrospun fibers had a good core-shell structure, and carried successfully about 0.5% FA. Besides, when volume ratio of the shell's mixed solvent (DCM and DMF) and the core's mixed solvent (anhydrous ethanol and DMF) changed, fiber diameter would increase with the decrease of DMF.

Key words: poly(1actic-co-glycolic acid), coaxial electrospinning, flurbiprofen axetil (FA), controlled-release preparations

中图分类号:

TQ340.6

朱同贺, 陈思浩, 楼建中, 王继虎, 李洋, 廖健俊. 基于静电纺丝技术的PLGA载药纳米纤维膜的制备工艺[J]. 化工进展, 2015, 34(3): 790-796.

ZHU Tonghe, CHEN Sihao, LOU Jianzhong, WANG Jihu, LI Yang, LIAO Jianjun. Preparation of drug-loaded polylactic acid-based fibers membranes based on electrospinning technology[J]. Chemical Industry and Engineering Progree, 2015, 34(3): 790-796.

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基于静电纺丝技术的PLGA载药纳米纤维膜的制备工艺

Preparation of drug-loaded polylactic acid-based fibers membranes based on electrospinning technology

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