乙酰丙酮锆催化乙丙交酯开环共聚的工艺研究

doi:10.16085/j.issn.1000-6613.2015.02.027

化工进展 ›› 2015, Vol. 34 ›› Issue (02): 479-483.DOI: 10.16085/j.issn.1000-6613.2015.02.027

乙酰丙酮锆催化乙丙交酯开环共聚的工艺研究

姜诚, 崔爱军, 姜海建, 孙政, 陈群

常州大学江苏省精细石油化工重点实验室, 江苏常州 213164

收稿日期:2014-05-12 修回日期:2014-05-21 出版日期:2015-02-05 发布日期:2015-02-05
通讯作者: 陈群,研究员。E-mail:13906123032@cczu.edu.cn
作者简介:姜诚(1989-),男,硕士研究生。E-mail:jc_frank@126.com

Process research on ring-opening copolymerization of glycolide and lactide by zirconium (Ⅳ) acetylacetonate

JIANG Cheng, CUI Aijun, JIANG Haijian, SUN Zheng, CHEN Qun

Key Lab of Jiangsu Province Fine Petrochemical Engineering, Changzhou University, Changzhou 213164, Jianggsu, China

Received:2014-05-12 Revised:2014-05-21 Online:2015-02-05 Published:2015-02-05

摘要/Abstract

摘要： 以乙酰丙酮锆[Zr(Acac)₄]为催化剂引发不同配比的乙交酯和L-丙交酯开环共聚反应,合成出了系列分子量的聚乙丙交酯(PLGA)。采用核磁共振(¹H NMR)、差示扫描量热(DSC)、热重分析(TGA)和X射线衍射(XRD)等方法表征了PLGA的结构和性质。结果表明,以乙酰丙酮锆催化制备的PLGA结晶度高于由传统催化剂辛酸亚锡制备的PLGA。研究了催化剂用量、聚合温度、聚合时间对聚乙丙交酯(PLGA)特性黏度的影响,得出了较优的反应工艺条件为:乙酰丙酮锆用量为0.06%,聚合温度为150℃,聚合时间为6h,合成了特性黏度达0.957 dL/g、重均相对分子质量为1.24×10⁵的高分子量的PLGA。

关键词: 乙酰丙酮锆, 乙交酯, L-丙交酯, 聚乙丙交酯, 开环共聚, 乙酰丙酮锆, 乙交酯, L-丙交酯, 聚乙丙交酯, 开环共聚

Abstract: Poly (glycolide-co-lactide) (PLGA) with a range of molecular weight was synthesized via a new method of copolymerization of glycolide with L-lactide by using zirconium (Ⅳ) acetylacetonate [Zr (Acac)₄] as initiator. The properties and structure of PLGA were characterized by NMR spectroscopy,differential scanning calormetry (DSC),thermogravimetric analysis (TGA) and X-ray diffraction (XRD). The crystallinity of copolymers obtained was higher than that formed in the presence of traditional catalyst Sn (Oct)₂. The effects of catalyst dosage,polymerization temperature and time were investigated. The optimal condition was as follows:zirconium (Ⅳ) acetylacetonate 0.06%,polymerization temperature 150℃,polymerization time 6h. Intrinsic viscosity of PLGA could reach 0.957dL/g and average molecular weight could reach 1.24×10⁵.

Key words: zirconium(IV) acetylacetonate, glycolide, L-lactide, Poly(glycolide-co-lactide), ring-opening copolymerization, zirconium(Ⅳ) acetylacetonate, glycolide, L-lactide, poly(glycolide-co-lactide), ring-opening copolymerization

中图分类号:

TQ316.4

姜诚, 崔爱军, 姜海建, 孙政, 陈群. 乙酰丙酮锆催化乙丙交酯开环共聚的工艺研究[J]. 化工进展, 2015, 34(02): 479-483.

JIANG Cheng, CUI Aijun, JIANG Haijian, SUN Zheng, CHEN Qun. Process research on ring-opening copolymerization of glycolide and lactide by zirconium (Ⅳ) acetylacetonate[J]. Chemical Industry and Engineering Progree, 2015, 34(02): 479-483.

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乙酰丙酮锆催化乙丙交酯开环共聚的工艺研究

Process research on ring-opening copolymerization of glycolide and lactide by zirconium (Ⅳ) acetylacetonate

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