Abstract:

Recombinant human growth hormone (rhGH) is the first choice to treat various growth hormone deficiencies and complications. But the rhGH requires long-term and frequent injection clinically. Long-acting rhGH preparations and non-injection administration routes can significantly increase patient compliance. In this paper, the types, effectiveness and development status of long-acting rhGH preparations and non-injection administration routes were reviewed. The research status and latest progress of rhGH long-acting methods (such as chemical modification, construction of fusion proteins, construction of sustained-release microspheres) and non-injection routes of rhGH (such as transdermal, pulmonary, nasal administrations) were introduced. The potential application problems of these rhGH delivery systems were analyzed, so that readers can have a more comprehensive and clear understanding of the research status in this field. The future development direction of this field was also proposed, that the rational combination of long-acting and non-injection administration would be an important research direction to achieve high-efficiency delivery of rhGH in the future. This paper provides a reference for the further development of a new safe and effective rhGH drug delivery system.

Key words: recombinant human growth hormone(rhGH), long-acting preparation, non-injection administration route

摘要：

重组人生长激素（rhGH）是治疗各种生长激素缺乏症及并发症的首选药物，但临床上需长期频繁注射给药，实现rhGH长效化和改变给药途径可显著提高患者依从性，具有重要的研究价值。本文针对近年来rhGH长效化制剂和非注射给药途径的类型、有效性及开发现状进行了综述，主要介绍了利用化学修饰、构建融合蛋白、构建缓释微球等rhGH长效化方法以及经皮给药、肺部给药、鼻腔黏膜给药等rhGH非注射给药途径的研究现状和最新进展，分析了各类rhGH给药系统在应用方面的潜在问题，以期使读者对该领域的研究状况有更全面、更清楚的了解；并指出了该研究领域未来的发展方向，提出了将rhGH长效化与非注射给药途径合理结合应是将来实现rhGH高效递送的重要研究方向，以期为进一步开发安全有效的rhGH新型给药系统提供参考。

关键词: 重组人生长激素, 长效化制剂, 非注射给药途径