Chemical Industry and Engineering Progree ›› 2012, Vol. 31 ›› Issue (03): 633-638.

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In situ product removal used in 2-phenylethanol production by microbial conversion

LI Huijing1YU Weiting2DAI Xiaomin1LIU Xiudong1MA Xiaojun2   

  1. 1School of Environment and Chemical Engineering,Dalian University,Dalian 116622,Liaoning,China;
    2Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,Liaoning,China)
  • Online:2012-03-05 Published:2012-03-05

微生物转化生产2-苯乙醇的原位产物转移技术研究进展

李会静1,于炜婷2,戴小敏1,刘袖洞1,马小军2   

  1. 1大连大学环境与化学工程学院,辽宁 大连 116622;2中国科学院大连化学物理研究所,辽宁 大连 116023)

Abstract: 2-phenylethanol(2-PEA)is an aromatic alcohol with rose fragrance,which has been widely used as an essence component in fine chemical and food industries. Compared with the low quality 2-PEA by chemical synthesis and the low yield and high price 2-PEA by plant extraction,2-PEA production by microbial conversion has been increasingly valued,but the product inhibition of 2-PEA to microbes is a problem. In situ product removal(ISPR)techniques can effectively improve 2-PEA yield by reducing product inhibition. The progress of ISPR techniques used in 2-PEA production by microbial conversion was introduced including the extraction,adsorption and membrane-based pervaporation and penetration extraction. The combination of ISPR techniques,high-efficient fermentation process and strain screening for high yield,the development of relatively simple instruments and post-processing techniques are suggested to be the research focus,so as to significantly improve the yield of 2-PEA and realize the industrialization of 2-PEA production by microbial conversion.

Key words: microbial conversion, 2-phenylethanol, in situ product removal

摘要: 阐述了微生物转化法生产天然2-苯乙醇的代谢途径以及2-苯乙醇对微生物的毒性即产物抑制作用,而原位产物转移技术(ISPR技术)可有效降低产物抑制作用,提高2-苯乙醇产量。着重介绍了微生物转化生产2-苯乙醇的ISPR技术的研究现状,比较总结了萃取、吸附与基于膜分离的渗透蒸发和渗透萃取技术的优缺点,提出今后的研究重点应是将开发ISPR技术与培育高产量菌株和高效发酵工艺相结合,利用相对简单的设备及后处理技术即可显著提高2-苯乙醇的产率,早日实现微生物转化生产2-苯乙醇的工业化。

关键词: 微生物转化法, 2-苯乙醇, 原位产物转移技术

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