Abstract: In order to prepare the composite salt of 2,3,5,6-tetraaminopyridine and 2-hydroxyterephthalic acid (TH salt) with high purity and yield，the 2,3,5,6-tetraaminopyridine hydrochloride(TAPH) was successfully reduced by catalytic hydrogenation from 3,5-dinitropyridine- 2,6-diamine(DADNP) as raw material. TAPH was obtained with the purity of 99.4% and the yield of 82.1% in hydrogen and 55～60℃ condition，the solvent is methanol and the catalyst is Pd/C. Under the protection of the nitrogencondition，the TAPH and 2-hydroxyterephthalic acid(HTA) sodiumsalt were taken as raw materials to make the composite salt of 2,3,5,6-tetraaminopyridine with 2-hydroxyterephthalic acid(TH salt). All chemical structures of the products were identified by 13C-NMR，MS and FT-IR，the result showed that the product was the aim product and its purity was up to 98%.

Key words: 2,3,5,6-tetraaminopyridine/2-hydroxyterephthalic acid composite salt (TH salt), 2,3,5,6-tetraaminopyridine hydrochloride(TAPH), 2-hydroxyterephthalic acid(HTA), 3,5-dinitropyridine-2,6-diamine(DADNP), 2,3,5,6-tetraaminopyridine/2-hydroxyterephthalic acid composite salt (TH salt) , 2,3,5,6-tetraaminopyridine hydrochloride(TAPH), 2-hydroxyterephthalic acid(HTA), 3,5- dinitropyridine-2,6-diamine(DADNP)

摘要： 为了制备高纯度与高收率的2,3,5,6-四氨基吡啶/2-羟基对苯二甲酸复合盐（TH盐），通过以2,6-二氨基-3,5二硝基吡啶（DADNP）为原料催化加氢还原制得2,3,5,6-四氨基吡啶盐酸盐（TAPH）。反应在55～60℃的氢气氛围下，以甲醇为溶剂，Pd/C为催化剂制得纯度99.4%的TAPH，收率82.1%。制成的盐酸盐再和2-羟基对苯二甲酸（HTA）钠盐在氮气氛围的保护下合成2,3,5,6-四氨基吡啶/2-羟基对苯二甲酸复合盐（TH盐）单体，结构经过13C-NMR、MS和FT-IR表征分析，结果表明是目的产物，纯度达98%以上。

关键词: 2,3,5,6-四氨基吡啶/2-羟基对苯二甲酸复合盐(TH盐), 2,3,5,6-四氨基吡啶盐酸盐（TAPH）, 2-羟基对苯二甲酸（HTA）, 2,6-二氨基-3,5二硝基吡啶（DADNP）, 2, 3, 5, 6-四氨基吡啶/2-羟基对苯二甲酸复合盐, 2, 3, 5, 6-四氨基吡啶盐酸盐, 2-羟基对苯二甲酸, 2, 6-二氨基-3, 5二硝基吡啶