Abstract: Bismuth (Ⅲ) acetate [Bi(OAc)3] was used as catalyst for the ring-opening polymerization of glycolide. The effects of catalyst content，polymerization temperature，polymerization time were investigated. The optimal condition was obtained as follows：Bismuth (Ⅲ) acetate 300 ?g/g，polymerization temperature 200 ℃，polymerization time 2h. The intrinsic viscosity of PGA could reach 0.884dL/g and average molecular weight could reach 1.12×105. The catalytic properties of Bi(OAc)3 and Sn(Oct)2 were compared. The catalytic activity of Bi(OAc)3 was slightly higher than Sn(Oct)2. The toxicity of PGA synthesized by Bi(OAc)3 and Sn(Oct)2 as the catalyst respectively was compared，and the former was lower than the latter obviously. The properties of PGA were characterized by X-ray diffraction (XRD)，differential scanning calormetry (DSC) and thermogravimetric analysis (TGA).

Key words: bismuth (Ⅲ) acetate, glycolide, polyglycolide, ring-opening polymerization, biodegradable materials

摘要： 以乙酸铋[Bi(OAc)3]为催化剂进行乙交酯的开环聚合，研究了催化剂用量、聚合温度、聚合时间对聚乙交酯（PGA）特性黏度的影响，得出了较优工艺条件为：乙酸铋用量为300 μg/g，聚合温度为200 ℃，聚合时间为2.0 h，合成了特性黏度高达0.884 dL/g、重均相对分子质量为1.12×105的高分子量PGA。比较了乙酸铋和辛酸亚锡的催化性能，结果表明，乙酸铋的催化活性略高于辛酸亚锡。比较了分别以乙酸铋和辛酸亚锡为催化剂合成的PGA的毒性，发现前者的毒性明显低于后者。用X射线衍射（XRD）、差示扫描量热（DSC）和热重分析（TGA）进行了性能表征。

关键词: 乙酸铋, 乙交酯, 聚乙交酯, 开环聚合, 生物可降解材料