Abstract: The macroscopic property and mass transfer enhancement of extracting Lincomycin with composite extractant (n-octanol and kerosene) in packed extraction column was studied in this paper. The structure of extracted complex and reaction equilibrium constant were determined by the slope method，which could contribute to the improvement of equipment and mass transfer enhancement. In order to improve the extraction efficiency，factors such as pH of the solution，volume ratio of the water phase to the organic phase，packing type，and distribution plates were considered. The results showed that in the extraction process of Lincomycin with n-octanol，the reaction equilibrium constant was 0.072，the optimum content of n-octanol in composite extractant was 0.8 (volume fraction)，the optimum pH of the extraction solution ranged from 10 to 11，the optimum volume ratio of the water phase to the organic phase was 3. Limited extraction efficiency was found to present in both structured packing and bulk packing extraction column. Distribution plates could significantly enhance the mass transfer in packed extraction column，with a maximum unit volume treatment capacity of 12.8 times compared to the extraction tank，and the circulation volume of extractant could be greatly reduced. The results can be used for guiding practical application of packed extraction column in Lincomycin extraction.

Key words: lincomycin, macroscopic property, distribution plates, packed extraction column

摘要： 以中试填料萃取塔为设备研究了复合萃取剂（正辛醇和煤油）萃取林可霉素的宏观特性及传质强化。使用斜率法确定萃合物的结构和反应平衡常数以指导改进设备和强化传质；为了提高林可霉素萃取效果，考察了溶液pH值、相比（W/O）、填料类型、分布盘的使用等因素对提取林可霉素效果的影响。结果表明：以正辛醇为萃取剂萃取林可霉素的过程中，反应平衡常数K为0.072；复合萃取剂中正辛醇最佳含量为0.8（体积分数）；萃取林可霉素的最佳pH值为10～11，最佳相比（W/O）为3；规整填料和散装填料萃取效果有限，分布盘可以大大加强传质，同时加装分布盘的填料萃取塔的单位体积处理量是混合澄清槽的12.8倍，萃取剂循环量大大减少。研究结果对复合萃取剂的萃取机理和填料萃取塔提取林可霉素的实际应用具有一定指导意义。

关键词: 林可霉素, 宏观特性, 分布盘, 填料萃取塔