Abstract: As a novel airlift loop reactor，Airlift Reversible Loop Reactor (ARLR) has been proved effectively increasing the gas holdup and mass transfer coefficient in fermentation experiments. By using computational fluid dynamics (CFD) simulation and experimental validation，the mass transfer characteristics of ARLR were studied. Through CFD simulation and response surface analysis，the structural parameters such as H/D ratio，draft tube diameter and draft tube height were optimized. Compared with traditional ALR，by using this novel reactor，the gas holdup increases 32% at least，and the oxygen mass transfer coefficient also increases more than 11%，under the same ventilation conditions. The results indicated that the ARLR has a very broad prospect in high aerobic microorganism cultivation.

Key words: Airlift Reversible Loop Reactor, CFD simulation, Gas holdup, Mass transfer coefficient, airlift reversible loop reactor (ARLR), CFD simulation, gas holdup, mass transfer coefficient

摘要： 气升式振荡环流反应器（ARLR）作为一种新型的气升式环流反应器，能够有效地提高反应器的气含率和传质系数，并已得到生物发酵实验的验证。本文通过CFD的手段研究了反应器内的流动和传质状况，并利用CFD模拟和响应面分析相结合的方法，优化了反应器的结构参数，如高径比（H/D）、升液区降液区面积之比、导流筒高度等。经过实验测量，优化后的气升式振荡环流反应器与传统的气升式环流反应器相比，气含率提高了32%以上，传质系数提高了11%以上。结果表明，气升式振荡环流反应器作为生化反应器有着非常广阔的应用空间。

关键词: 气升式振荡环流反应器, 数值模拟, 气含率, 传质系数, 气升式振荡环流反应器, 数值模拟, 气含率, 传质系数