Abstract:

Simulated moving bed (SMB) draws much attention as a very efficient separation technique for binary mixtures，and has extended its application to pharmaceutical industry. Recently，many improvements on SMB have been proposed to handle the increasingly difficult separation cases. In this review，these improvements are classified according to configuration and operating mode. Meanwhile，the principles as well as ideas of these improvements are introduced，and the developing trend of SMB is presented．

摘要：

模拟移动床作为一种高效的吸附分离技术一直备受关注，其应用领域逐步延伸至制药行业，用于手性药物和生物制品的分离。近年来，为了满足日益复杂和困难的分离需求，一些新型的模拟移动床分离技术被相继提出。本文从模拟移动床的结构设计和操作模式两个方面对这些新型技术进行归类，着重综述和评价了它们的技术原理和开发思路，并展望了模拟移动床分离技术的研究方向和发展趋势。