Abstract:

D-glucaric acid is a dicarboxylic acid containing polyhydroxy. It can be obtained from many glucose-based substances and be used to prepare products of biodegradable polymers，pharmaceuticals and food. In this review，we try to describe the principles and preparation methods of D-glucaric acid in both chemical（nitric acid oxidation and TEMPO oxidation）and biological fields，and review its applications in both pharmaceuticals（anticancer drugs and imaging agents）and polymers.

摘要：

葡萄糖二酸是含有多羟基的二元酸，广泛来源于葡萄糖基物质，可用于可降解聚合物、药物和食品等产品的制备。本文介绍了硝酸氧化、TEMPO氧化等化学法和生物法制备葡萄糖二酸的原理和方法，并综述了其在抗癌及显像剂药物、聚合物等方面的应用。