Abstract:

Calcium alginate microspheres with mean diameter of 820 nm and calcium alginate/chitosan microcapsules were prepared by emulsion-curing. Effects of drug concentration，the molecular weight and concentration of chitosan on drug-loading and drug-release of the microcapsules were investigated using bovine serum albumin（BSA）as a model drug. The maximum drug-loading was over 40%，and the microcapsules also showed good property of sustained-release in vitro.

摘要：

采用乳化固化法制备了平均粒径为820 nm海藻酸钙微球，并制备了海藻酸钙/几丁聚糖微胶囊。以牛血清白蛋白（BSA）为模型药物，考察投药浓度、几丁聚糖分子量和浓度等对微胶囊载药量和药物释放的影响，发现其载药量最大可达40%以上，结果还显示这种微胶囊具有很好的体外缓释性能。