Abstract: Camostat mesilate，a drug for pancreatitis treatment was prepared from p-guanidinobenzoic acid hydrochloride and N,N-dimethylcarbamoylmethyl-p-hydroxyphenylacetate in the presence of DCC（N,N-dicyclohexylcarbodiimide）using DMAP（4-dimethylaminopyridine）as catalyst. p-Guanidinobenzoic acid hydrochloride was prepared from p-aminobenzoic acid and cyanamide by optimization of reaction conditions. This process is simple with easily available starting materials，which is suitable for industrial production.

摘要： 研究了抗胰腺炎药甲磺酸卡莫司他的合成工艺，以对氨基苯甲酸和氰胺为原料，通过优化反应条件，合成了对胍基苯甲酸盐酸盐，它与对羟基苯乙酸-N,N-二甲基氨基甲酰甲酯在二环己基碳二亚胺（DCC）参与下，用4-二甲氨基吡啶（DMAP）作催化剂制备了目标产物，该方法操作简便，原料易得，易于工业化推广。