Abstract: To improve the alkali-extraction process in benzypenicillin sodium salt production，a continuous-process technology was adopted instead of the conventional intermittent production. Based on extraction principles，optimum process conditions were obtained by using orthogonal experimental design，which were found as 6% sodium carbonate solution，5min for vibration shock and 12.1cm2 sub-phase boundary area. An industrial test run was carried out under these conditions，the first extraction yield was entirely higher than 96% and the second extraction yield was higher than 99.9%.

摘要： 对溶媒萃取工艺生产青霉素钠盐的碱化抽提工序进行改进，采用连续式生产代替传统的间歇式生产。根据萃取原理，采用正交试验设计，对实验数据进行优化处理，确定了适宜的工艺条件：碳酸钠质量分数6%，震荡时间5 min，分相界面积12.1 cm2。在该适宜条件下，进行了工业小试，得到的一次萃取收率均在96%以上，二次萃取收率均在99.9%以上。