Abstract: Process systems engineering（PSE）is playing an increasingly important role in the development of biorefinery. This paper introduces the existing application of PSE in process development，enterprise production and regional system design of biorefinery. To meet the requirements of biorefinery development，the possibility and necessity of PSE application in bio-reaction process simulation，enterprise production process optimization and production management optimization are discussed. Two important future directions of PSE’s application in biorefinery are proposed，one of which is the effort in large-scale system analysis for a complete biorefinery system including agriculture and forestry， and the other is the interdisciplinary cooperation with economics，management science and other sciences.

摘要： 过程系统工程在生物炼制发展的过程中发挥着越来越重要的作用。本文介绍了过程系统工程相关技术在生物炼制工艺开发、企业生产和区域系统设计中的应用情况。针对生物炼制发展过程中的要求，讨论了过程系统工程技术在生物反应过程模拟、企业生产过程优化、生产管理优化等研究方向应用的可能性与必要性。文章认为，过程系统工程应用于生物炼制领域有两个重要的未来发展方向，一是针对包括农林业生产在内的生物炼制产业链的大系统分析，二是加强同经济学、管理学等其它学科领域的交叉融合。