Abstract: Collagen and collagen-based materials are widely used in biomedicine，leather，food and daily chemical industries. During the processing，application and preservation，the collagen is often exposed to UV irradiation，placed in the environment with varied temperature，humidity or pH，immersed in salt solutions，or eroded by bacillus，which resulted in the structure and properties changes of collagen materials. This article reviews the influence of several important factors on the structure and properties of collagen. The influence of UV irradiation，solutions and heat on the changes in thermal stability，triple helices structure and aggregation structure is summarized.

摘要： 胶原及胶原基材料广泛应用于生物医用、皮革、食品、日用化学工业等领域。在加工、应用及保存的过程中，胶原常会受到光照、温度及湿度变化、pH值变化、盐溶液浸泡以及细菌和霉菌侵蚀等作用，使材料的结构发生改变，导致性能变化。本文综述了引起胶原结构与性能变化的主要因素，阐述了紫外光照射、酸与碱溶液、盐溶液与有机溶剂及热作用下，胶原的热稳定性能、三股螺旋链结构及聚集态结构的变化。