Abstract: The industrial process for acetophenone production is by the reaction of benzene with acetyl chloride, which produces strong acid, and is an environmental pollution process. A alternative approach for the synthesis of acetophenone by liquid-phase oxidation of ethylbenzene is studied using manganese sulfate as catalyst and oxygen as oxidant. With optimized reaction conditions [5mL of ethylbenzene, 4.9% of MnSO4, n（Br）/n（Mn）=2.0, 10 mL of glacial acetic acid, 100mL/min of oxygen flow at 90℃ with 4 h of reaction time], conversion of ethylbenzene and yield of acetophenone reached to 72.36% and 59.57%, respectively.

摘要： 工业上多采用苯和乙酰氯合成苯乙酮，但此法生成强酸，环境污染严重。本文研究了以硫酸锰为催化剂，氧为氧化剂，液相催化氧化乙苯制备苯乙酮的新方法。在最佳反应条件，即乙苯5 mL、硫酸锰用量为乙苯的4.9%、n(Br)/n(Mn)=2.0、冰乙酸10 mL、氧气流速为100 mL/min，温度90 ℃的条件下反应4 h，乙苯转化率和苯乙酮收率分别为72.36%和59.57%。